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. 2021 Apr 12;9(4):E552–E561. doi: 10.1055/a-1352-2709

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The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.

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Fig. 6 — Less vascular density/size in intramucosal signet-ring cell carcinoma areas. Representative histological images of colitis-associated tumor containing intramucosal high-grade dysplasia (HGD) and signet-ring cell carcinoma (Sig) components (Case #S1). HE staining (upper left) shows intramucosal HGD containing a Sig component which is lined by a yellow dotted line. CD34 staining indicates intramucosal vessels in these lesions (lower left). The rectangle HGD (red line) and Sig (blue line) areas in the CD34 staining are magnified to the upper right. Further magnified HE staining and VEGF staining were shown below. Scale bars, 200 μm.