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. 2021 Apr 8;13:3081–3100. doi: 10.2147/CMAR.S292992

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© 2021 Guo et al.

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The mechanisms of PI3K/Akt/mTOR pathway and MAPK pathway, and inhibitors in ovarian cancer clinical development. Illustration the therapy strategy via inhibiting the PI3K/Akt/mTOR pathway (green) and MAPK pathway (amaranth) in ovarian cancer patients with PIK3CA and KRAS gene mutation. The orange represents a different inhibitory effect of repressing tumor growth by targeting different sites on the PI3K/Akt/mTOR pathway. For patients with PIK3CA gene mutation, clinical treatment drugs are mainly divided into PI3K inhibitor, AKT inhibitor, and mTOR inhibitor. The blue represents a different inhibitor target MAPK pathway in ovarian cancer patients with KRAS gene mutation. The therapy strategy includes restricting KRAS bound to GTP and targeting its downstream signaling pathway.