Table 1.
The Frequency of the Four Gene Mutations Among Epithelial Ovarian Cancer
| Subtype | Frequency of Genetic Alterations | Ref. | |||
|---|---|---|---|---|---|
| TP53 | BRCA1/2 | PIK3CA | KRAS | ||
| HGSOC | 96% | 22%~40% | 2.9% | 5.9% | [23,143–145] |
| LGSOC | 8.3 | 10% | 12.5% | 54% | [7,61,146,147] |
| EnOC | 5–54.5% | 11.1% | 31.4% | 10.3% | [61,97,120,148,149] |
| OCCC | 10% | 4.5% | 51% | 15% | [61,93,99,121,150] |
| Mucinous | 56.8% | 0 | 13.5% | 57.1~64.9% | [120,126,151,152] |
Abbreviations: HGSOC, high-grade serous ovarian carcinoma; LGSOC, low-grade serous ovarian carcinoma; EnOC, endometrioid ovarian carcinoma; OCCC, ovarian clear cell carcinoma.