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. 2021 Apr 8;13:3067–3077. doi: 10.2147/CMAR.S290059

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© 2021 Yi et al.

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circ_0001806 up-modulated NOVA2 expression by down-modulating miR-1182. (A) TargetScan database predicted that there was a binding sequence between miR-1182 and NOVA2. (B) The binding sequence between miR-1182 and NOVA2 was detected by dual-luciferase reporter gene experiment. (C–F) qRT-PCR and Western blot were utilized to detect NOVA2 mRNA and NOVA2 expression in H1650 and HCC827 cells. (G) qRT-PCR was employed to detect NOVA2 mRNA expression in NSCLC cancer tissues and adjacent tissues. (H and I) The correlation between NOVA2 mRNA and circ_0001806 or miR-1182 expression in NSCLC tissues. **, ***represent P < 0.01, P < 0.001.