Table 4.

Predictors for progression to end-stage kidney disease in the Cox proportional hazards model

Variable	Univariate		Model 1a		Model 2b
	HR (95% CI)	p-value	aHR (95% CI)	p-value	aHR (95% CI)	p-value
Age	1.03 (1.01−1.06)	0.015	1.02 (0.99−1.04)	0.210	1.01 (0.99−1.04)	0.263
Sex	1.22 (0.67−2.20)	0.514	1.23 (0.66−2.28)	0.520	1.32 (0.72−2.40)	0.372
Diabetes	1.42 (0.60−3.37)	0.425
Hypertension	1.85 (1.03−3.33)	0.039	0.95 (0.50−1.79)	0.871	1.15 (0.61−2.17)	0.674
eGFR at diagnosis	0.90 (0.86−0.95)	<0.001	0.91 (0.87−0.96)	<0.001	0.95 (0.91−1.00)	0.049
Percentage of glomeruli
Normal	0.96 (0.94−0.98)	<0.001
Crescentic	1.01 (1.00−1.02)	0.156
Sclerotic	1.02 (1.01−1.04)	<0.001
Histopathologic classification
Focal	Reference		Reference
Crescentic	3.40 (0.98−11.85)	0.054	2.45 (0.69−8.67)	0.165
Mixed	5.04 (1.48−17.19)	0.010	4.23 (1.23−14.58)	0.022
Sclerotic	9.88 (2.66−36.62)	0.001	5.05 (1.32−19.31)	0.018
Clinicopathologic classification
Low	Reference				Reference
Medium	4.40 (1.01−19.23)	0.049			2.56 (0.54−12.12)	0.237
High	18.63 (4.38−79.17)	<0.001			6.56 (1.25−34.26)	0.026

aHR, adjusted hazard ratio; CI, confidence interval; eGFR, estimated glomerular filtration rate; HR, hazard ratio.

^aModel 1 for histopathologic classification: adjusted for age, sex, hypertension, and eGFR at diagnosis.

^bModel 2 for clinicopathologic classification: adjusted for age, sex, hypertension, and eGFR at diagnosis.