Table 1.
Comparison of clinical and laboratory parameters between high KDPI donor (or recipient) and low KDPI donor (or recipient)
| Variable | High KDPI | Low KDPI | p-value |
|---|---|---|---|
| Donor | 257 | 269 | |
| Age at KT (yr) | 55.0 ± 8.9 | 35.5 ± 12.3 | <0.001 |
| Sex, male:female | 171:86 | 197:72 | 0.106 |
| BMI (kg/m2) | 23.1 ± 3.2 | 22.6 ± 3.9 | 0.223 |
| HTN | 96 (37.4) | 11 (4.1) | <0.001 |
| DM | 44 (17.1) | 6 (2.2) | <0.001 |
| Cause of donor death, CVA | 196 (76.3) | 167 (62.1) | <0.001 |
| eGFR (mL/min/1.73 m2) | |||
| Baseline | 79.7 ± 20.1 | 87.8 ± 28.9 | 0.001 |
| At allocation | 51.6 ± 29.6 | 94.9 ± 44.6 | <0.001 |
| CKD stage 3 or above stage | 174 (67.7) | 83 (30.9) | <0.001 |
| AKI | 178 (69.3) | 115 (42.8) | <0.001 |
| Stage 1 | 61 (23.7) | 52 (19.3) | |
| Stage 2 | 55 (21.4) | 27 (10.0) | |
| Stage 3 | 62 (24.1) | 36 (13.4) | |
| ECD | 148 (57.6) | 1 (0.4) | <0.001 |
| Recipient | 338 | 319 | |
| Transplant year | 0.004 | ||
| 1996–2005 | 0 (0) | 8 (2.5) | |
| 2006–2010 | 44 (13.0) | 55 (17.2) | |
| 2011–2016 | 294 (87.0) | 256 (80.3) | |
| Age at KT (yr) | 51.3 ± 10.1 | 47.6 ± 9.8 | <0.001 |
| Sex, male:female | 201:137 | 188:131 | 0.937 |
| BMI (kg/m2) | 23.3 ± 3.5 | 23.0 ± 4.1 | 0.297 |
| HTN | 290 (85.8) | 263 (82.4) | 0.242 |
| DM | 82 (24.3) | 55 (17.2) | 0.028 |
| Dialysis duration before KT (yr) | 7.3 ± 11.7 | 8.8 ± 8.6 | 0.289 |
| Previous KT | 25 (7.4) | 45 (14.1) | 0.008 |
| Cause of ESRD | 0.003 | ||
| Glomerulonephritis | 142 (42.0) | 156 (48.9) | |
| DM | 70 (20.7) | 44 (13.8) | |
| HTN | 70 (20.7) | 45 (14.1) | |
| Others | 56 (16.6) | 74 (23.2) | |
| Cold ischemic time (min) | 247.9 ± 118.7 | 254.2 ± 129.8 | 0.531 |
| HLA mismatch number | 3.8 ± 1.5 | 3.5 ± 1.5 | 0.014 |
| Induction | 0.017 | ||
| Basiliximab | 224 (66.3) | 239 (74.9) | |
| ATG | 114 (33.7) | 80 (25.1) | |
| Major immunosuppressant, tacrolimus:cyclosporine | 335 : 3 | 312 : 6 | 0.251 |
| PRA > 50 % | 50 (14.8) | 64 (20.1) | 0.048 |
| Follow-up duration (mo) | 44.1 ± 28.7 | 52.2 ± 39.9 | 0.003 |
Data are expressed as number only, mean ± standard deviation, or number (%).
eGFR is calculated using Chronic Kidney Disease Epidemiology Collaboration.
AKI, acute kidney injury; ATG, antithymocyte globulin; BMI, body mass index; CKD, chronic kidney disease; CVA, cerebrovascular accident; DM, diabetes mellitus; ECD, expanded criteria donor; eGFR, estimated glomerular filtration rate; ESRD, end-stage renal disease; HLA, human leukocyte antigen; HTN, hypertension; KDPI, Kidney Donor Profile Index; KT, kidney transplantation; PRA, panel-reactive antibody.