Table 1.
Demographic information about the patients and controls from whom brain tissue was obtained for binding assays (AD case numbers 1–8) and autoradiography studies (AD patients A and B and control C). The sex, age at death, apolipoprotein (ApoE) genotype, Braak stage at cerebral pathological assessment, presence of early- or late-onset AD and post-mortem delay are provided
| Case no. | Sex (M/F) | Age (years) | ApoE (E/E) | Braak stage | EOAD/LOAD | Post-mortem delay (hours:minutes) | |
|---|---|---|---|---|---|---|---|
| AD patients | 1 | F | 59 | 4/4 | 5 | EOAD | 04:20 |
| 2 | F | 66 | 4/3 | 5 | EOAD | 06:30 | |
| 3 | M | 70 | 4/4 | 4 | EOAD | 04:00 | |
| *4 | M | 77 | NA | 6 | LOAD | 06:35 | |
| 5 | M | 78 | 4/4 | 5 | LOAD | 06:35 | |
| 6 | F | 81 | 4/3 | 5 | LOAD | 06:15 | |
| *7 | F | 82 | NA | 6 | LOAD | 04:20 | |
| *8 | F | 85 | 3/3 | 4 | LOAD | 06:00 | |
| Mean | 3 M/5F | 72 ± 13 |
5 E4 1 E3 |
4–6 | 3 EOAD/5 LOAD | ||
| A | F | 79 | 4/4 | 5 | LOAD | 16:00 | |
| B | M | 81 | 4/4 | 6 | LOAD | 17:00 | |
| Controls | 9 | F | 50 | 3/3 | 1 | N/A | 04:10 |
| 10 | M | 62 | 3/3 | 1 | N/A | 07:20 | |
| 11 | F | 71 | 3/3 | 1 | N/A | 07:10 | |
| 12 | F | 77 | 3/3 | 1 | N/A | 02:55 | |
| 13 | M | 78 | 3/3 | 1 | N/A | 17:40 | |
| 14 | M | 79 | 3/3 | 2 | N/A | 09:00 | |
| 15 | F | 84 | 3/3 | 1 | N/A | 06:55 | |
| Mean | 3 M/4F | 67 ± 17 |
7 E3 0 E4 |
1–2 | |||
| C | F | 76 | 1 | N/A | 04:00 |
Values in italics indicate AD patients (numbers 1, 4, 5) whose temporal lobes were used for the saturation and competition studies, and the 59-year-old AD patient (number 1) whose parietal lobe was used. The asterisks ‘*’ indicate AD patients (numbers 4, 7, 8) whose hippocampus was used for the competition studies
AD, Alzheimer’s disease; EOAD, early-onset AD; F, female; LOAD, late-onset AD; M, male; N/A, not applicable