. 2020 Sep 24;48(4):1093–1102. doi: 10.1007/s00259-020-05035-y

Table 2.

Percentage of ³H-MK6240 binding sites in the temporal cortex (or ³H-THK5351 binding sites in the hippocampus) for which the unlabelled compound (THK5117, AV-1451 or MK6240) had a super-high affinity in competitive studies

Radioligand	Competitor	Fraction of sites with super-high affinity for the competitor (%)	R²
³H-MK6240	AV-1451	74	0.60
	THK5117	37	0.60
	MK6240	58	0.70
³H-THK5351	AV1451 *	35	0.96
	THK5117*	46	0.96
	MK6240	0	N/A

*See Lemoine et al. [12] for competitive studies using ³H-THK5351 versus unlabelled THK5117 or AV-1451

N/A, not applicable; R², regression coefficient