Table 4.
Study | Age at different assessments (in months) | Total number of participants | Number of EL siblings | Number of siblings with ASD outcome | Number of siblings with TD outcome | Number of siblings with another outcomea | Topic | Assessment method | Diagnostic instruments | Difference EL-ASD vs EL-TD and/or predicts ASD diagnosis | Main findings |
---|---|---|---|---|---|---|---|---|---|---|---|
St. John et al. (2018) US [45] | 12, 24 | 262 | 186 | 19 | 106 | – | Executing functioning: working memory (WM), response inhibition | A-not-B task | ADOS-2, ADI-R, expert clinical judgment according to DSM-IV-TR | No |
At 12 m no between-group difference in WM or response inhibition was found From 12 to 24 m the performance of TL, but not of EL-ASD and EL-TD improved At 24 m EL-ASD and EL-TD showed worse WM and inhibition performance compared to TL. No significant difference between EL-ASD and EL-TD was found |
aAtypical outcome: deficit in general cognition, motor functioning, language delay, Broader Autism Phenotype (BAP, social communication delay)