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. 2021 Apr 12;4:478. doi: 10.1038/s42003-021-01944-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Top, Pelguer–Huet characteristic neutrophil and eosinophil and lymphocyte chromatin defects are shown (blood from female animals are presented, but no sex-specific effect has been observed). Black arrows in LBR NT-KO animals indicate defects in chromatin organization in the shown cell types. Scale bar indicates 5 µm. b No skin/fur defects were observed in LBR NT-KO animals. A female adult WT and a LBR NT-KO mouse are shown next to each other are shown. c No skeletal defects in front (left) and rear (right) paws have been observed in any analyzed category (female animals are shown in this figure, but no sex-specific effect has been observed). Scale bar indicates 1 mm. d The table shows perinatal mortality from different classes of crosses indicating the parental origin of the mutation (father: ft; mother: mt). born: born; wean: weaned; peri-mort: perinatal mortality; mutation classes are shown. A one-way ANOVA (Kruskal–Wallis test), followed by a post hoc multiple comparison tests (Dunn’s test) have been used to compare the number of weaned mice in each group to the WT/WT condition (the analysis was done per litter).