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. 2021 Apr 12;11:7911. doi: 10.1038/s41598-021-87207-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Box plots of FGF21 levels at baseline (dark blue) and after short-term treatment (medium blue) as well as after longer-term treatment (light blue) in patients randomized to placebo or anakinra from Trial B, respectively. P-values were determined using a linear mixed model. Each box signifies the upper and lower quartiles, while the median is represented by a line within the box. Whiskers represent the upper and lower adjacent values, outliers are depicted as dots.