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. 2021 Apr 12;11:7937. doi: 10.1038/s41598-021-87199-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Immunohistochemistry showed that CCL11 and CCR3 were expressed in rheumatoid arthritis (RA) synovial tissues (STs) and fibroblast-like synoviocytes (FLS). (A) CCL11 and CCR3 were observed in the RA STs lining layers (magnification × 400). (B) CCL11 and CCR3 were expressed in RA FLS and were increased in FLS stimulated with 50 ng/mL TNF-α compared with the unstimulated FLS (magnification × 200). NS no stimulation.