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. 2021 Apr 12;11:7937. doi: 10.1038/s41598-021-87199-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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CCL11 induced the migration of RA FLS and THP-1 cells. (A) CCL11-stimulated RA FLS were significantly more efficient at migration than unstimulated FLS (n = 3 patients, 3 experiments each). (B) CCL11 siRNA treatment decreased the expression of CCL11 mRNA (n = 3 patients). (C) CCL11 siRNA treatment decreased the migration of RA FLS (n = 2 patients, 3 experiments each). NS no stimulation. The data are expressed as the mean ± SEM. *p < 0.05 was significant.