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. 2021 Apr 12;4:453. doi: 10.1038/s42003-021-01986-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a The modular architecture of mature vWF. vWF-binding protein (vWbp) binds to the A1 domain. b Cartoon depicting S. aureus ClfA and vWbp in a hypothetical complex with vWF under the shear stress of arterial blood flow. Tangled and coiled globular vWF is stretched out by the arterial flow. vWbp mediates ClfA-dependent binding of S. aureus to vWF via its A1 domain.