Table 3.
DEGs involved in the biological processes, categorized by Reactome server (transcriptomes induced after exposure of hBMECs to Lbp).
| No | Pathway identifier | Pathway name | Number of entities found | Number of entities total | Number of entities FDR | Number of reactions found | Number of reactions total | Reactions ratio |
|---|---|---|---|---|---|---|---|---|
| 1 | R-HSA-1280215 | Cytokine Signaling in Immune system | 65 | 1055 | 8.90e−14 | 244 | 639 | 0.0533 |
| 2 | R-HSA-6783783 | Interleukin-10 signaling | 13 | 86 | 1.34e−13 | 2 | 15 | 0.0013 |
| 3 | R-HSA-449147 | Signaling by Interleukins | 40 | 640 | 5.45e−11 | 199 | 491 | 0.0410 |
| 4 | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 17 | 211 | 3.19e−09 | 25 | 46 | 0.0038 |
| 5 | R-HSA-168256 | Immune System | 107 | 2663 | 2.06e−06 | 493 | 1526 | 0.1273 |
| 6 | R-HSA-913531 | Interferon signaling | 21 | 392 | 2.06e−06 | 15 | 66 | 0.0055 |
| 7 | R-HSA-380108 | Chemokine receptors bind chemokines | 13 | 48 | 3.59e−06 | 8 | 18 | 0.0015 |
| 8 | R-HSA-909733 | Interferon alpha/beta signaling | 11 | 184 | 4.54e−04 | 4 | 20 | 0.0017 |
| 9 | R-HSA-877300 | Interferon gamma signaling | 13 | 250 | 5.03e−04 | 4 | 15 | 0.0013 |
| 10 | R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 8 | 89 | 0.009 | 15 | 22 | 0.0018 |
| 11 | R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | 5 | 17 | 0.027 | 9 | 12 | 0.0010 |
| 12 | R-HSA-1474244 | Extracellular matrix organization | 25 | 329 | 0.027 | 93 | 318 | 0.0265 |
| 13 | R-HSA-446107 | Type I hemidesmosome assembly | 4 | 11 | 0.044 | 6 | 6 | 5.01e−04 |
| 14 | R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 9 | 67 | 0.046 | 10 | 26 | 0.0022 |