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. 2021 Apr 12;12:2149. doi: 10.1038/s41467-021-22380-0

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a–d Diagrams of cross-sections of reovirus virions, infectious subvirion particles (ISVPs), and cores. Schematics depict the arrangement and conformation of structural proteins in the double-layered shells of the virions in the absence (a) and presence (b) of Neu5Ac (triggering a conformational change of σ1); removal of σ3, cleavage of μ1, and rearrangement of σ1 in ISVPs (c); and removal of μ1 fragments, loss of σ1, and opening of the λ2 turret in cores (d).