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. 2021 Apr 12;7:76. doi: 10.1038/s41420-021-00450-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — ACh is synthesized in the T cells by enzyme choline acetyltransferase. Adrenergic innervation stimulates production of the T-cell-derived ACh, which is involved in regulating the tumor immunity and tumor biology behavior. Endoneural macrophages also regulate tumor metastasis through CXCL10. CXCL10 recruits the myeloid cells and suppresses T cells via VISTA and PD-L1.