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. 2021 Apr 12;11:7887. doi: 10.1038/s41598-021-86878-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Model for the effect of the CD25890 gene on sporulation initiation in C. difficile. CD25890 responds to the nutrient sources and indirectly influences the sinRR’ operon expression through an unknown mechanism which represses sporulation-specific gene expression via spo0A expression. This mechanism may involve the transcriptional factors, CD03700, CD21430 and CD24890, which are differentially expressed in the CD25890 mutant. CodY and CcpA are global regulators that also respond to nutrient cues and impact sporulation by directly repressing sinRR’ expression. Solid line, direct effect; dotted line, indirect effect.