Table 2.
Fixed effects of risk factors on baseline eGFR and changes of eGFR in patients with DM.
| Fixed effects | Model 1 | Model 2 | Model 3 | |||
|---|---|---|---|---|---|---|
| Coefficient, ml/min/1.73m2 (95% CI) | P value | Coefficient, ml/min/1.73m2 (95% CI) | P value | Coefficient, ml/min/1.73m2 (95% CI) | P value | |
| Effects on baseline eGFR (intercept) | ||||||
| Sex (male) | − 5.47* (− 9.51 to − 1.43) | 0.008 | − 6.18* (− 10.27 to − 2.08) | 0.003 | − 4.61* (− 9.04 to − 0.18) | 0.04 |
| Age (per 1 year older) | − 0.55* (− 0.69 to − 0.40) | < 0.001 | − 0.51* (− 0.66 to − 0.37) | < 0.001 | − 0.50* (− 0.66 to − 0.35) | < 0.001 |
| BMI (per kg/m2) | 0.11 (− 0.11 to 0.33) | 0.32 | 0.08 (− 0.19 to 0.34) | 0.58 | ||
| SBP (per 1 mmHg greater) | 0.02 (− 0.01 to 0.05) | 0.13 | 0.01 (− 0.03 to 0.05) | 0.57 | ||
| Smoking (yes vs no) | 1.74 (− 1.85 to 5.33) | 0.34 | ||||
| HbA1c (per 1%) | − 0.25 (− 0.93 to 0.43) | 0.47 | ||||
| UPCR (per 10 mg/g) | 0.01 (-0.01 to 0.02) | 0.09 | ||||
| Effects on changes of eGFR (slope) | ||||||
| Sex (male) | − 0.17 (− 1.46 to 1.12) | 0.80 | − 0.20 (− 1.65 to 1.26) | 0.79 | 0.66 (− 1.20 to 2.52) | 0.49 |
| Age (per 1 year older) | 0.01 (− 0.03 to 0.05) | 0.60 | 0.03 (− 0.02 to 0.07) | 0.22 | 0.01 (− 0.04 to 0.05) | 0.86 |
| BMI (per kg/m2) | − 0.08 (− 0.17 to 0.01) | 0.05 | − 0.06 (− 0.16 to 0.04) | 0.25 | ||
| SBP (per 1 mmHg greater) | − 0.01 (− 0.02 to 0.01) | 0.74 | 0.01 (− 0.02 to 0.03) | 0.83 | ||
| Smoking (yes vs no) | − 0.53 (− 1.58 to 0.52) | 0.33 | ||||
| HbA1c (per 1%) | − 0.06 (− 0.45 to 0.33) | 0.78 | ||||
| UPCR (per 10 mg/g greater) | − 0.01* (− 0.02 to − 0.01) | < 0.001 | ||||
Model 1: sex and baseline age. Model 2: sex, baseline age, BMI, and SBP. Model 3: sex, baseline age, BMI, SBP, smoking, HbA1c, and UPCR.
eGFR estimated glomerular filtration rate, DM diabetes mellitus, CI confidence interval, BMI body mass index, SBP systolic blood pressure, HbA1c hemoglobin A1c, UPCR urine protein-creatinine ratio.
*P < 0.05.