Table 3.
Fixed effects of risk factors with baseline eGFR and changes of eGFR in patients without DM.
| Fixed effects | Model 1 | Model 2 | Model 3 | |||
|---|---|---|---|---|---|---|
| Coefficient, ml/min/1.73m2 (95% CI) | P value | Coefficient, ml/min/1.73m2 (95% CI) | P value | Coefficient, ml/min/1.73m2 (95% CI) | P value | |
| Effects on baseline eGFR (intercept) | ||||||
| Sex (male) | − 11.26* (− 13.98 to − 8.54) | < 0.001 | − 11.14* (− 13.51 to − 8.77) | < 0.001 | -10.85* (− 13.26 to − 8.44) | < 0.001 |
| Age (per 1 year older) | − 0.54* (− 0.62 to − 0.45) | < 0.001 | − 0.43* (− 0.49 to − 0.36) | < 0.001 | − 0.44* (− 0.51 to − 0.37) | < 0.001 |
| BMI (per kg/m2) | − 0.16 (− 0.36 to 0.04) | 0.12 | − 0.18 (− 0.38 to 0.03) | 0.09 | ||
| SBP (per 1 mmHg greater) | 0.01 (− 0.01 to 0.04) | 0.30 | 0.002 (− 0.02 to 0.03) | 0.90 | ||
| Smoking (yes vs no) | 0.43 (− 2.65 to 3.52) | 0.78 | ||||
| UPCR (per 10 mg/g) | − 0.002 (− 0.01 to 0.002) | 0.28 | ||||
| Effects on changes of eGFR (slope) | ||||||
| Sex (male) | 1.41* (0.77 to 2.06) | < 0.001 | 0.80* (0.10 to 1.50) | 0.03 | 0.59 (− 0.02 to 1.20) | 0.06 |
| Age (per 1 year older) | − 0.01 (− 0.02 to 0.02) | 0.71 | − 0.01 (− 0.02 to 0.02) | 0.91 | 0.01 (− 0.01 to 0.02) | 0.67 |
| BMI (per kg/m2) | 0.06 (− 0.02 to 0.13) | 0.14 | 0.03 (− 0.04 to 0.10) | 0.39 | ||
| SBP (per 1 mmHg greater) | 0.02* (0.01 to 0.03) | 0.02 | 0.02* (0.01 to 0.04) | 0.01 | ||
| Smoking (yes vs no) | − 0.25 (− 0.97 to 0.46) | 0.49 | ||||
| UPCR (per 10 mg/g greater) | 0.001 (− 0.01 to 0.01) | 0.77 | ||||
Model 1: sex and baseline age. Model 2: sex, baseline age, BMI, and SBP. Model 3: sex, baseline age, BMI, SBP, smoking, HbA1c, and UPCR.
eGFR estimated glomerular filtration rate, DM diabetes mellitus, CI confidence interval, BMI body mass index, SBP systolic blood pressure, UPCR urine protein-creatinine ratio.
*P < 0.05.