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. 2021 Mar 13;24(4):102303. doi: 10.1016/j.isci.2021.102303

Figure 1.

Figure 1

cARKO female mice showed impaired muscle strength induced by DHT treatment

(A) Experimental scheme. Nine-week-old female control and cARKO mice were implanted with a pellet containing 10 mg DHT. Grip strength and tissue weight were measured at 13 weeks old.

(B) Serum DHT levels were determined in 13-week-old female Control_Sham (n = 8), Control_DHT (n = 7), cARKO_Sham (n = 5), and cARKO_DHT (n = 6) mice.

(C) Ar mRNA expression levels in gastrocnemius muscles of 13-week-old female Control_Sham (n = 4), Control_DHT (n = 3), cARKO_Sham (n = 4), and cARKO_DHT (n = 5) mice.

(D) Immunostaining of AR in TA muscles. Scale bars: 100 μm.

(E) Grip strength were measured in 13-week-old female Control_Sham (n = 9), Control_DHT (n = 7), cARKO_Sham (n = 9), and cARKO_DHT (n = 7) mice.

(F–I) body weight (F), TA muscle weight (G), quadriceps muscle weight (H), and gastrocnemius muscle weight (I) were measured in 13-week-old female Control_Sham (n = 8), Control_DHT (n = 7), cARKO_Sham (n = 5), and cARKO_DHT (n = 6) mice. Data are represented as mean ± standard deviation. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001. One-way analysis of variance followed by Student Newman-Keuls tests.

See also Figure S1.