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. 2021 Apr 12;11:7979. doi: 10.1038/s41598-021-87260-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Facial deformities in Col2-SW mice are mainly developed in nasal septum-associated structure. (a) Micro-CT images of mouse skulls in the midsagittal plane at P7 and P21. The red arrows indicate the closure between the premaxilla and the vomer. The red arrowheads indicate palate perforation. Scale bar: 1 mm. (b) Hematoxylin, eosin, and Alcian blue staining of skulls of P7 mice in the midsagittal plane. The dotted line indicates the edge of each bone. Abbreviations: n, nasal bone; f, frontal bone; pm, premaxilla bone; v, vomer; et, ethmoid bone; m, maxilla; ns, nasal septum. Scale bar: 1 mm. (c) Superior view of the skull. The white arrows on the mutant mice indicate the deviation of the nasal bone. Scale bar: 2 mm. (d) Micro-CT images of the perpendicular plate of the ethmoid bone at P21. (e) Measurement of perpendicular plate of ethmoid bone volume. Scale bar: 1 mm. Values are presented as means ± standard deviations. *p ≤ 0.0332, **p ≤ 0.0021 (n = 5).