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. 2021 Apr 12;11:7953. doi: 10.1038/s41598-021-87217-8

Figure 3.

Figure 3

Systemic AGP knockout exacerbates AKI to CKD progression. (A) Blood urea nitrogen (BUN) and (B) body weights were measured up to day 14 after renal IR. hAGP administration (2 mg/mouse/day, ip, from day 0 (before IR) to day 7) to AGP KO mice suppressed IR-induced the increase of BUN. Date are expressed as means ± SE. *P < 0.05, **P < 0.01 compared with WT mice at each time point. #P < 0.05, ##P < 0.01 compared with AGP KO mice at each time point. (C) Kim-1 mRNA expression in the kidney at day 14 after renal IR was determined by real-time PCR. (D) Representative photomicrographs of PAS-stained kidney sections at day 14 after renal IR are shown. Lower panels of PAS are an enlarged image of the upper panel. Original magnification: × 200 (upper panels), × 400 (lower panels). Scale bars represent 100 μm. hAGP administration to AGP KO mice rescued IR-induced renal injury. Data are expressed as the means ± SE (n = 4–8).