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. 2021 Apr 12;6:52. doi: 10.1038/s41541-021-00314-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Vaccine-induced HIV-1-specific CD8 T-cell responses from spleen of mice (n = 4 per group) primed intramuscularly with recombinant DNA, infected with 10⁷ PFUs of NYVAC-C or NYVAC-C Δ3 and injected with FTY720 every other day starting from the day before infection (a). Neutrophil total numbers in peritoneal cavity (PEC), spleen, and blood of NYVAC-C Δ3-injected and FTY720- or PBS-injected mice (b). The response was measured 11 days after the last immunization, after splenocyte stimulation with HIV-1 peptides. Contour plots of CD8 T cells that produce IFN-γ, TNF, and CD107a after NYVAC-C or NYVAC-C Δ3 infection (c). Total numbers (d) or percentages of Pol-1-, Pol-2-specific (e) CD8 T cells that express IFN-γ and/or TNF and/or CD107a. Nonspecific responses of mice infected with control NYVAC-WT were subtracted from the total value. Graphs show mean ± confidence interval (CI). Pie chart colors indicate the relative percentage of cells producing three (black), two (gray), or one (white) activation markers (f). Data are representative of two independent experiments. ***P < 0.001.