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. 2021 Apr 12;11:7862. doi: 10.1038/s41598-021-87329-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Difference in methylation ratios (square root transformed; y-axis) for normal/low-grade and high-grade cervical disease according to histological outcome (CIN2 + and CIN3; x-axis); normal/CIN0 (green circles, n = 6), CIN1 (yellow circles, n = 8), CIN2 (orange circles, n = 8), and CIN3 (red circles, n = 11). Box-plots indicate median methylation levels of (a) GHSR, (b) SST, (c) ZIC1, (d) ASCL1, (e) LHX8, and (f) ST6GALNAC5 and according interquartile ranges (25th and 75th percentile). P-values (Mann Whitney U-test) indicated by a double asterisk mean that the null hypothesis (H0) is rejected (p ≤ 0.05) and that the median square root transformed methylation marker ratios between normal/low-grade and high-grade cervical disease are not equal. P-values indicated by a single asterisk indicate a trend (0.05 < p ≤ 0.10).