Table 1.
Performance of individual host cell methylation markers to discern high-grade cervical disease.
| Marker | P-value MWUa | AUC (95% CI)b | ||||
|---|---|---|---|---|---|---|
| Cytology | Histology | Cytology | Histology | |||
| HSIL + | CIN2 + | CIN3 | HSIL + | CIN2 + | CIN3 | |
| GHSR | 0.128 | 0.004** | 0.014** | 0.622 (0.488–0.757) | 0.801 (0.591–0.919) | 0.769 (0.561–0.897) |
| SST | 0.049** | 0.251 | 0.221 | 0.658 (0.498–0.798) | 0.620 (0.464–0.789) | 0.634 (0.473–0.809) |
| ZIC1 | 0.345 | 0.228 | 0.588 | 0.568 (0.435–0.707) | 0.620 (0.489–0.788) | 0.558 (0.400–0.742) |
| ASCL1 | 0.125 | 0.068* | 0.524 | 0.614 (0.451–0.778) | 0.677 (0.497–0.819) | 0.566 (0.473–0.849) |
| LHX8 | 0.198 | 0.009** | 0.087* | 0.598 (0.480–0.741) | 0.763 (0.575–0.890) | 0.682 (0.465–0.842) |
| ST6GALNAC5 | 0.177 | 0.061* | 0.244 | 0.609 (0.465–0.725) | 0.695 (0.501–0.846) | 0.628 (0.453–0.804) |
Performance of each marker was assessed using cytology (HSIL + , n = 89) and histology (CIN2 + and CIN3, n = 33) as reference.
aP-values (Mann Whitney U-test (MWU)) indicated by a double asterisk indicate that the null hypothesis (H0) is rejected (p ≤ 0.05) and that the median square root transformed methylation marker ratios between normal/low-grade and high-grade cervical disease are not equal. P-values values indicated by a single asterisk indicate a trend (0.05 < p ≤ 0.10).
bAn estimation of the performance of each marker was evaluated by the area under the curve (AUC) and accompanying 95% confidence interval (CI).