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. 2021 Apr 12;5:30. doi: 10.1038/s41698-021-00168-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Illustrates the clinical validity results for PDOs as a predictive biomarker for treatment response (dark red: significant correlation and/or predictive value found, pink: trend for correlation or predictive value found, blue: no correlation and white: not tested), with the size of the circle representing the patient cohort size, specified per treatment and tumour type (y-axis) and ex vivo drug response parameter (x-axis). Abbreviations: 5-FU 5-fluorouracil, AC-T doxorubicin + cyclophosphamide + paclitaxel, AUC area under the curve, Capec. capecitabine, CAPIRI capecitabine + irinotecan, CRC colorectal cancer, EOX epirubicin + oxaliplatin + 5-FU, FOLFIRI 5-FU + irinotecan, FOLFOX 5-FU + oxaliplatin, GC gastric cancer, GOC gastroesophageal cancer, GR growth rate inhibition metrics, GR50 value with 50% viable GR, HNSCC head and neck squamous cell carcinoma, ICI immune checkpoint inhibitors, OMI optical metabolic imaging, PDO patient-derived organoid.