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. 2021 Mar 16;24(4):102315. doi: 10.1016/j.isci.2021.102315

Figure 7.

Figure 7

Working Model

Description is in the main text. Events preventing (A) or stimulating (B) reticulophagy are shown. Although several aspects of this working model are supported by Hullinger et al. (2016); Pehar et al. (2012); Peng et al. (2014, 2016, 2018); Peng and Puglielli (2016); and Rigby et al. (2020), there are different components that remain to be fully dissected. The most urgent questions include: (1) the structural mechanism that allows CALR to recognize the acetylated lysine residues and sequester ATG9A and (2) the specific role of HSPB1, as well as the structural requirements that underlie the apparent different behavior of monomeric and oligomeric HSPB1.