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. 2021 Mar 30;11:555614. doi: 10.3389/fonc.2021.555614

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Copyright © 2021 Yoon, Brezden-Masley and Streutker

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Case information for the 86 gastric/gastro-esophageal junction (GEJ) adenocarcinoma cases, displaying their LC3B/p62 (cytoplasmic) staining patterns, along with immunohistochemical (IHC) intensity for LC3B, p62 (cytoplasmic, nuclear), and LAMP2A for each case. Also displayed are their respective histotype, approximated TCGA molecular subtype (see Methods), and tumor differentiation. (B, C) Kaplan-Meier curves, showing overall survival of the St. Michael’s gastric/GEJ adenocarcinoma cohort, divided by (B) macroautophagic subtypes (LC3B/cytoplasmic p62), and (C) nuclear p62 intensity.