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. 2021 Mar 30;14:643763. doi: 10.3389/fnmol.2021.643763

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Copyright © 2021 Schlabitz, Monni, Ragot, Dipper-Wawra, Onken, Holtkamp and Fidzinski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activity-dependent c-FOS expression in human slices. (A) Example of a typical IOS image of a SLE in a human cortex slice at 60 s after start. (B) Example of an electrophysiological trace showing a SLE recorded in human cortical layers II/III upon application of aCSF containing 8 mM potassium and 100 μM 4-AP. (C) Scatter plots showing c-FOS expression fold changes relative to basal condition. All data are normalized to the reference gene RPL13A and expressed as median ± interquartile range. c-FOS expression in slices displaying SLE activity is higher when compared to basal condition (**p < 0.01, n = 5).