Table 1.
Demographic data of patients with DLB or AD/DLB and non-DLB following the disclosure of clinical data
| Final clinical diagnosis |
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| Probable DLB (n = 32) | Prodromal DLB (n = 5) | DLB/AD (n = 6) | AD (n = 10) | Probable CJD a (n = 10) | PSP (n = 8) | CBS (n = 1) | FTD (n = 3) | Others b (n = 6) | |
| Gender M/F | 23/9 | 3/2 | 3/3 | 7/3 | 5/5 | 4/4 | 0/1 | 3/0 | 2/4 |
| Age (years) | 73.9 ± 6.0 | 75.4 ± 4.0 | 66.3 ± 9.6 | 69.3 ± 9.6 | 66 ± 16 | 73.5 ± 5.0 | 70 | 72.0 ± 1.6 | 53 ± 24.4 |
| MMSE score at diagnosis | 23.2 ± 4.5 | 28.0 ± 1.6 | 18.3 ± 7.4 | 23.9 ± 1.4 | N.E. | 27.6 ± 2.9 | 28 | 23.3 ± 1.0 | 27.2 ± 4.2 |
| Interval between clinical onset and OM swabbing (mo) | 39.0 ± 27.2 | 26.2 ± 14.9 | 31.8 ± 31.0 | 26.0 ± 15.0 | 3.3 ± 1.8 | 20.7 ± 14.9 | 36 | 37.3 ± 9.6 | 33.6 ± 43 |
| MMSE score at OM brushing | 19.7 ± 5.6 | 27.8 ± 1.5 | 16.2 ± 8.0 | 22.7 ± 3.0 | N.E. | 25.6 ± 4.6 | 30 | 16.7 ± 5.0 | 26.5 ± 3.7 |
| Interval between clinical onset and lumbar puncture (mo) | 25.6 ± 27.4 (n = 10) | 24 (n = 1) | 17.7 ± 12.6 (n = 6) | 23.8 ± 14.2 (n = 10) | 3.3 ± 1.8 (n = 10) | 22.4 ± 17.1 (n = 5) | 30 | 31.3 ± 12.7 (n = 3) | 18.7 ± 6.2 (n = 4) |
| Alzheimer’s disease CSF profile § | 0/10 | 0/1 | 5/5 | 9/10 | 0/10 | 0/4 | 0 | 0/3 | 0/4 |
a
All CJD patients received a definite diagnosis.
b
Clinical diagnoses included: Psychosis (n = 2), Down syndrome (n = 1), vascular dementia (n = 1); mild cognitive impairment (n = 1) and Arnold-Chiari malformation type 1 (n = 1);