Figure 7.

ScRNA-seq analysis of IPF, SSc-ILD, and control stromal cell populations. (A) UMAP plot of stromal cell populations, identified by cell type. (B) UMAP plot of stromal cell populations, identified by disease status. (C) Pathways upregulated in IPF endothelial cells compared to SSc-ILD endothelial cells (D) Pathways upregulated in SSc-ILD endothelial cells compared to IPF endothelial cells (E) Expression of selected genes in all non-lymphatic endothelial cells, separated by disease state. scRNA-seq, single-cell RNA-sequencing; IPF, idiopathic pulmonary fibrosis; SSc-ILD, systemic sclerosis-associated interstitial lung disease; UMAP, uniform manifold approximation and projection.