TABLE 1.

Potential FoxO1 modulators and their effects in DKD.

Modulators	Cellular targets	Effects on FoxO1-mediated pathway and cell physiology	Experimental model of DKD	References
Puerarin	↑Sirt1 expression	↑PGC-1α/FoxO1 deacetylation ↓ROS ↑Mn-SOD and CAT activity	T1D mice	Xu et al. (2016)
Liraglutide	↓FoxO1 phosphorylation	↑FoxO1 activity ↑Mn - SOD expression ↓ECM production	T2D rats	Chen et al. (2018)
Resveratrol	↑Sirt1 activity	↑FoxO1 deacetylation ↑SOD activity ↓MDA expression ↓Col IV and FN expression	T2D rats	Hussein and Mahfouz (2016)
Atrasentan	↓miR-21 expression	↑FoxO1 expression	Podocytes cultured in HG, T2D (KK-Ay) mice	Wang et al. (2019a)
Progranulin	↑Sirt1 expression	↑PGC-1α/FoxO1 deacetylation ↓Mitophagy ↑Mitochondrial biogenesis	Podocytes cultured in HG, T1D mice	Zhou et al. (2019)
Metformin	↑AMPK/Sirt1	↑FoxO1 activity ↓ROS ↑Autophagy ↓Cell proliferation	Mesangial cells cultured in HG, T2D rats	Ren et al. (2020)

T1D, type 1 diabetes; T2D, type 2 diabetes; Mn-SOD, manganese superoxide dismutase; CAT, catalase; SOD, superoxide dismutase; MDA, malondialdehyde; ROS, reactive oxygen species; Col, collagen; FN, fibronectin.