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. 2021 Mar 30;12:652160. doi: 10.3389/fimmu.2021.652160

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Copyright © 2021 Maes, Mondino, Lasarte, Agirre, Vanderkerken, Prosper and Breckpot

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Epigenetic factors that regulate TADC activity. Epigenetic enzymes that foster DC-activation include MLL complex (HMT); KDM6B and KDM4D (HDM); HDAC1 and 2 as well as TET2. Collectively these enzymes regulate the expression of genes involved in antigen presentation and stimulation of CTL-responses, such as CIITA, CD40, CD80, CD86, IL12 and IFNA/B. In contrast, enzymes such as the G9a (HMT), HDAC2, and the DNMT1, DNMT3A and DNMT3B rather inhibit DC-activity by acting on genes such as IL6, IFNA/B, CCL2, SOCS3 and IL1R. G9a, DOTL1, HDAC2 and DNMT represent potential targets to improve DC mediated anti-tumor immunity. iDC, immature dendritic cell; mDC, mature dendritic cell; HMT, histone methyltransferase; HDM, histone demethylases; HDAC, histone deacetylases.