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. 2021 Mar 30;12:652160. doi: 10.3389/fimmu.2021.652160

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Copyright © 2021 Maes, Mondino, Lasarte, Agirre, Vanderkerken, Prosper and Breckpot

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The epigenetic landscape of MDSC. EZH2 and HDAC11 serve as negative regulators of MDSC differentiation from immature myeloid. In MDSC, the bromodomain (BRD) of CBP/p300 acts as a critical regulator of H3K27Ac across promoters and enhancers of pro-tumorigenic target genes such as Arg-1 and NOS2. Also, increased DNMT3A levels have been shown in MDSC and have been linked to repression of immunity-related genes such RUNX1, S1PR4, FAS and AQP9. CBP/p300 and its bromodomain or DNMT3A represent potential targets to inhibit MDSC. MDSC, myeloid derived suppressor cell; HDAC, histone deacetylase.