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. 2021 Mar 30;12:652160. doi: 10.3389/fimmu.2021.652160

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Copyright © 2021 Maes, Mondino, Lasarte, Agirre, Vanderkerken, Prosper and Breckpot

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Epigenetic regulation of CD8⁺ T cell differentiation. Naive CD8⁺T cells are characterized by a bivalent state of permissive (green) and repressive (red) histone marks in genes related to differentiation and proliferation while effector genes are not decorated by permissive marks or repressive marks. Effector CD8⁺T cells show permissive (green) marks in effector genes while the transcription factor Tcf1 and memory and effector genes contain repressive (red) marks. Memory CD8⁺T cells show permissive (green, purple) marks in effector, memory and survival genes while Tcf1 is not DNA methylated, supporting their multipotent state. EZH2 and DNMT3A represent potential targets to increase CD8⁺ T memory formation.