Table 6.

ADME prediction of final selected 10 alkaloids using pre-ADMET tool

No.	Compound	Human intestinal absorption (HIA, %)	Caco-2 cell permeability (nm/s)	MDCK cell permeability (nm/s)	Skin permeability (logKp, cm/h)	Blood brain barrier penetration (C.brain/C.blood)
1	Moronic acid	97.629	22.270	0.043	‒1.96099	4.35022
		(well absorbed)	(middle)	(low)		(high)
2	Cadambagenic acid	94.671	21.010	0.044	‒2.90457	2.72322
		(well absorbed)	(middle)	(low)		(high)
3	Maslinic acid	84.065	21.302	0.805	‒5.13957	0.258554 (middle)
		(well absorbed)	(middle)	(low)
4	Nortripterifordin	95.204	21.983	112.722	‒3.06612	2.51705
		(well absorbed)	(middle)	(middle)		(high)
5	Michellamine	90.663	20.059	0.043	‒3.17237	2.32226
		(well absorbed)	(middle)	(low)		(high)
6	Cadambine	67.555	3.851	0.054	‒5.17586	0.0374348
		(medium absorbed)	(middle)	(low)		(low)
7	Repandusinic acid	00.000	15.834	0.043	‒2.63834	0.0277558
		(no absorbed)	(middle)	(low)		(low)
8	3a-Dihydrocadambine	52.205	6.134	0.073	‒5.11884	0.035656
		(medium absorbed)	(middle)	(low)		(low)
9	Hinokiflavone	86.954	7.156	0.084	‒3.36300	0.280203 (middle)
		(well absorbed)	(middle)	(low)
10	Robustaflavone	81.196	12.043	0.043	‒3.45363	0.122688 (middle)
		(well absorbed)	(middle)	(low)

ADME properties showed that these compounds are good lead molecules.