Table 2.
The list of genes, proteins encoded, genetic alterations, loci, frequency of alteration, and variant allele frequency in genes of the Wnt signaling pathway
| Gene | Protein | Alteration | Loci | % of alteration | Variant allele frequency in tumor sample | gnomAD data |
|---|---|---|---|---|---|---|
| WNT1 | Wnt family member 1 | Deep deletion | 12q13.12 | 0.6 | ||
| D49N | 0.16 | Novel | ||||
| WNT2 | Wnt family member 2 | Gene amplification | 7q31.2 | 1.6 | ||
| Deep deletion | ||||||
| S158R | 0.42 | Novel | ||||
| T315P | 0.23 | Novel | ||||
| T315N | 0.57 | Novel | ||||
| WNT2B | Wnt family member 2B | Deep deletion | 1p13.2 | 2 | ||
| R16L | 0.63 | Novel | ||||
| WNT3 | Wnt family member 3 | Gene amplification | 17q21.31‒q21.32 | 1 | ||
| R85Q | 0.68 | rs1483494147 | ||||
| E2Q | 0.18 | Novel | ||||
| A261P | 0.46 | Novel | ||||
| G318D | 0.21 | Novel | ||||
| WNT3A | Wnt family member 3A | Gene amplification | 1q42.13 | 1.2 | ||
| P283L | 0.33 | Novel | ||||
| WNT4 | Wnt family member 4 | Gene amplification | 1p36.12 | 0.6 | ||
| E76Q | 0.26 | Novel | ||||
| S176Efs*12 | 0.13 | Novel | ||||
| WNT5A | Wnt family member 5A | Deep deletion | 3p14.3 | 1.4 | ||
| I93V | 0.28 | rs750646727 | ||||
| G341S | 0.20 | rs1370251695 | ||||
| R215C | 0.57 | Novel | ||||
| WNT5B | Wnt family member 5B | Gene amplification | 12p13.33 | 3 | ||
| Deep deletion | ||||||
| G242W | 0.36 | Novel | ||||
| WNT6 | Wnt family member 6 | Deep deletion | 2q35 | 1.8 | ||
| R46W | 0.29 | rs766635655 | ||||
| T105M | 0.23 | rs759013954 | ||||
| WNT7A | Wnt family member 7A | Gene amplification | 3p25.1 | 0.8 | ||
| Deep deletion | ||||||
| R90C | 0.28 | rs751362548 | ||||
| WNT7B | Wnt family member 7B | Gene amplification | 22q13.31 | 0.8 | ||
| Q261E | 0.10 | Novel | ||||
| WNT8A | Wnt family member 8A | Deep deletion | 5q31.2 | 0.6 | ||
| G12A | 0.25 | Novel | ||||
| L346V | 0.32 | Novel | ||||
| WNT8B | Wnt family member 8B | Deep deletion | 10q24.31 | 1.4 | ||
| W63C | 0.36 | Novel | ||||
| R157Q | 0.34 | Novel | ||||
| A59S | 0.12 | Novel | ||||
| A94S | 0.02 | Novel | ||||
| WNT9A | Wnt family member 9A | Gene amplification | 1q42.13 | 2.2 | ||
| R333Q | 0.17 | Novel | ||||
| D156N | 0.25 | Novel | ||||
| E37K | 0.41 | Novel | ||||
| V290M | 0.18 | Novel | ||||
| R61W | 0.14 | Novel | ||||
| A264V | 0.28 | Novel | ||||
| WNT9B | Wnt family member 9B | Gene amplification | 17q21.32 | 0.8 | ||
| P35A | 0.20 | Novel | ||||
| Y353H | 0.15 | Novel | ||||
| L102P | 0.18 | Novel | ||||
| WNT10A | Wnt family member 10A | Deep deletion | 2q35 | 1.8 | ||
| A240V | 0.16 | rs201578578 | ||||
| G88D | 0.28 | Novel | ||||
| WNT10B | Wnt family member 10B | Gene amplification | 12q13.12 | 0.4 | - | - |
| Deep deletion | ||||||
| WNT11 | Wnt family member 11 | Gene amplification | 11q13.5 | 5 | ||
| Deep deletion | ||||||
| L65P | 0.61 | rs1173549137 | ||||
| R202H | 0.07 | rs374455490 | ||||
| WNT16 | Wnt family member 16 | Gene amplification | 7q31.31 | 1.6 | ||
| Deep deletion | ||||||
| E271Q | 0.20 | Novel | ||||
| S218* | 0.18 | Novel | ||||
| G304W | 0.09 | Novel |