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. 2021 Mar 30;9:650961. doi: 10.3389/fbioe.2021.650961

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Copyright © 2021 Burgardt, Moustafa, Persicke, Sproß, Patschkowski, Risse, Peters-Wendisch, Lee and Wendisch.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic overview of metabolic engineering of C. glutamicum for CoQ10 production. Heterologous plasmid-driven expression of genes is visualized in green boxes. Chromosomal overexpression of native and heterologous genes is visualized in yellow boxes. Deletion of genes is visualized in red. E4P, erythrose 4-phosphate; DAHP, 3-deoxy-D-arabinoheptulosonate 7-phosphate; 3DHQ, 3-dehydroquinate; 3DHS, 3-dehydroshikimic acid; PCA, protocatechuic acid; pHBA, para-hydroxybenzoate; GAP, glyceraldehyde 3-phosphate; PEP, phosphoenolpyruvate; MEP, 2-C-methylerythritol 4-phosphate; IPP, isopentenyl diphosphate; DMAPP, dimethylallyl diphosphate; GPP, geranyl diphosphate; FPP, farnesyl diphosphate; GGPP, geranylgeranyl diphosphate; DPP, decaprenyl diphosphate, 10P-HB, 3-decaprenyl-4-hydroxybenzoate; 10P-Ph, 2-decaprenylphenol; 10P-HPh, 2-decaprenyl-6-hydroxyphenol; 10P-MPh, 2-decaprenyl-6-methoxyphenol; 10P-MBQ, 2-decaprenyl-6-methoxy-1,4-benzoquinol; 10P-MMBQ, 2-decaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; 10P-MHMBQ, 2-decaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol; CoQ₁₀H₂, ubiquinol-10; CoQ₁₀, ubiquinone-10; aroG^FBR, feedback-resistant DAHP synthase from E. coli; aroB, 3-dehydroquinate synthase; qsuC, 3-dehydroquinate dehydratase; qsuB, 3-dehydroshikimate dehydratase; qsuD, shikimate dehydrogenase; aroE, shikimate dehydrogenase; ubiC^FBR, feedback-resistant chorismate-pyruvate lyase from E. coli; entC, isochorismate synthase; pobA, para-hydroxybenzoate hydroxylase; idi, isopentenyl diphosphate isomerase; crtE, geranylgeranyl diphosphate synthase; idsA, geranylgeranyl diphosphate synthase; ispA, farnesyl diphosphate synthase; crtOP, cg0717-cg0723; crtB2I’I2, cg2668-cg2672; ddsA, decaprenyl diphosphate synthase from P. denitrificans; ubiA, 4-hydroxybenzoate octaprenyltransferase; ubiD, 3-octaprenyl-4-hydroxybenzoate decarboxylase; ubiX, flavin prenyltransferase; ubiI, 2-octaprenylphenol hydroxylase; ubiG, 2-octaprenyl-6-hydroxyphenol/2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol methyltransferase; ubiH, 2-octaprenyl-6-methoxyphenol hydroxylase; ubiE, ubiquinone/menaquinone biosynthesis methyltransferase; ubiF, 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; ubiB, probably protein kinase, function unknown.