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. 2021 Apr 13;7:77. doi: 10.1038/s41420-021-00464-6

Table 1.

Details of persisting symptoms of children with COVID-19, according to sex.

Patient and disease features Total M F P value
n = 129 n = 67 n = 62
Age 11.0 (4.4) 11.2 (4.5) 10.8 (4.4) 0.585
Symtomatic acute COVID-19 96 (74.4%) 50 (74.6%) 46 (74.2%) 1
Hospitalized during acute COVID-19 6 (4.7%) 5 (7.5%) 1 (1.6%) 0.247
Admitted in PICU 3 (2.3%) 2 (3%) 1 (1.6%) 1
Timing of survey after acute COVID-19 diagnosis (days) 0.56
<60 31 (24%) 17 (25.4%) 14 (22.6%)
60–119 30 (23.3%) 13 (19.4%) 17 (27.4%)
120 or more 68 (52.7%) 37 (55.2%) 31 (50%)
Any persisting symptoms at time of survey 0.909
None 54 (41.9%) 28 (41.8%) 26 (41.9%)
1–2 46 (35.7%) 23 (34.3%) 23 (37.1%)
3 or more 29 (22.5%) 16 (23.9%) 13 (21%)
Signs and symptoms reported
Fatigue_ 0.703
Less 1 (0.8%) 1 (1.5%) 0 (0%)
A bit less 16 (12.4%) 9 (13.4%) 7 (11.3%)
Same 98 (76%) 50 (74.6%) 48 (77.4%)
A bit more 13 (10.1%) 7 (10.4%) 6 (9.7%)
More 1 (0.8%) 0 (0%) 1 (1.6%)
Nasal congestion 16 (12.4%) 9 (13.4%) 7 (11.3%) 0.919
Difficulty breathing 8 (6.2%) 4 (6%) 4 (6.5%) 1
Pain on breathing 5 (3.9%) 3 (4.5%) 2 (3.2%) 1
Chest pain 4 (3.1%) 2 (3%) 2 (3.2%) 1
Persistent cough 7 (5.4%) 6 (9%) 1 (1.6%) 0.147
Persistent muscle pain 13 (10.1%) 8 (11.9%) 5 (8.1%) 0.661
Joint pain 9 (7%) 5 (7.5%) 4 (6.5%) 1
Headache 13 (10.1%) 3 (4.5%) 10 (16.1%) 0.057
Altered smell 6 (4.7%) 2 (3%) 4 (6.5%) 0.606
Altered taste 4 (3.1%) 1 (1.5%) 3 (4.8%) 0.557
Lack of concentration 13 (10.1%) 6 (9%) 7 (11.3%) 0.883
Insomnia 24 (18.6%) 10 (14.9%) 14 (22.6%) 0.374
Hypersomnia 4 (3.1%) 3 (4.5%) 1 (1.6%) 0.668
Weight loss 10 (7.8%) 7 (10.4%) 3 (4.8%) 0.389
Poor appetite 10 (7.8%) 6 (9%) 4 (6.5%) 0.84
Diarrhea 2 (1.6%) 1 (1.5%) 1 (1.6%) 1
Abdominal pain 3 (2.3%) 1 (1.5%) 2 (3.2%) 0.946
Constipation 8 (6.2%) 5 (7.5%) 3 (4.8%) 0.801
Skin rash 9 (7%) 6 (9%) 3 (4.8%) 0.568
Palpitations 5 (3.9%) 3 (4.5%) 2 (3.2%) 1
Changes menstruation 2 (1.6%) 0 (0%) 2 (3.2%) 0.442
Do these symptoms distress your child? 0.976
Not at all 66 (51.2%) 34 (50.7%) 32 (51.6%)
Only a little 36 (27.9%) 18 (26.9%) 18 (29%)
Quite a lot 14 (10.9%) 8 (11.9%) 6 (9.7%)
A great deal 2 (1.6%) 1 (1.5%) 1 (1.6%)
Preferred not to say 11 (8.5%) 6 (9%) 5 (8.1%)
Quality of life Before COVID-19 96.3 (5.3) 96.0 (5.5) 96.7 (5.0) 0.476
Quality of life at the time of the survey 92.9 (9.1) 92.9 (9.1) 92.8 (9.3) 0.987