Relationship between lipoprotein(a)-cholesterol [Lp(a)-C] and Lp(A) molar concentrations in all individuals (A), those treated with IONIS-APO(a)Rx ASO (B), and those treated with placebo ASO (C). Relationship between % Lp(a)-C and Lp(A) mass in all individuals (D), those treated with IONIS-APO(a)Rx ASO (E), and those treated with placebo ASO (F). Data from baseline, trough, and recovery time points are represented in each panel. In panels C and F, each color in the legend references one individual. apo(a), apolipoprotein(a); ASO, antisense oligonucleotide.