Table 3.
Spearman correlation coefficients (P values) between Lp(a)-C and various Lp(a) and plasma lipoprotein parameters in 29 individuals with elevated baseline Lp(a) enrolled in a Lp(a)-lowering ASO clinical trial
| Lp(a) molar (nM) | Lp(a)-C (mg/dl) | % Lp(a)-C | |
|---|---|---|---|
| TC (mg/dl) | 0.24 (P = 0.03) | 0.39 (P < 0.001) | 0.36 (P = 0.001) |
| LDL-C (mg/dl) | 0.25 (P = 0.02) | 0.29 (P = 0.008) | 0.25 (P = 0.024) |
| LDL-Ccorr (mg/dl) | 0.1 (P = 0.4) | 0.1 (P = 0.35) | 0.19 (P = 0.09) |
| HDL-C (mg/dl) | 0.02 (P = 0.9) | 0.05 (P = 0.687) | 0.11 (P = 0.320) |
| TG (mg/dl) | −0.06 (P = 0.6) | 0.16 (P = 0.162) | 0.28 (P = 0.010) |
| Lp(a) mass (mg/dl) | 0.91 (P <0.001) | 0.69 (P < 0.001) | −0.25 (P = 0.023) |
| Lp(a) molar (nM) | 1 | 0.76 (P < 0.001) | −0.07 (P = 0.541) |
| OxPL-apoB (nM) | 0.85 (P < 0.001) | 0.65 (P < 0.001) | 0.1 (P = 0.104) |
| Lp(a)-C (mg/dl) | 0.76 (P < 0.001) | 1 | 0.42 (P < 0.001) |
| % Lp(a)-C | −0.07 (P = 0.5) | 0.42 (P < 0.001) | 1 |
%Lp(a)-C, percent Lp(a)-C/Lp(a) mass; OxPL-apoB, oxidized phospholipid on apolipoprotein B-100.
Three time points (baseline, trough, and recovery) from each of the 29 individuals were included in this correlation analysis.
Statistically significant correlations are given in bold.