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. 2021 Feb 6;62:100030. doi: 10.1016/j.jlr.2021.100030

Fig. 3.

Fig. 3

The W246G mutation in ELOVL4 impairs VLC-SFA synthesis but retains the ability to synthesize VLC-PUFA. A: Analysis of VLC-SFA in skin. Levels of VLC-SFA (28:0 and 30:0) and total VLC-SFA (28:0 + 30:0) were significantly reduced in the skin of MUT rats compared with WT and HET rats. B: Levels of 26:0, the direct precursor for VLC-SFA synthesis, did not differ significantly across genotypes. However, levels of 24:0 were significantly elevated in the skin of HET and MUT rats compared with WT rats. (Data shown as mean ± SD. Analysis by one-way ANOVA with Tukey's post hoc test. ∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001). C: VLC-PUFA were detected specifically in the phosphatidylcholine fraction (PC), but total VLC-PUFA levels showed no differences among WT, HET, and MUT rat retinas. However, significant differences were detected in non-VLC-FA species (PC 34:01 and PC 40:06) among genotypes.