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. 2021 Feb 2;11(5):1519–1539. doi: 10.1016/j.jcmgh.2021.01.012

Figure 2.

Figure 2

Role of FXR and FGF19 in NASH. OCA-dependent FXR activation induces secretion in the portal circulation of FGF19, which reaches the liver through the portal circulation and binds the receptor FGFR4 with the co-receptor β klotho, repressing CYP7A1 expression and thus reducing BA synthesis. The effects of FXR activation improve liver steatosis, inflammation, and fibrosis. In addition, FGF19 is able to repress CYP7A1 expression, ameliorating body weight, BMI, insulin concentration, and serum ALT/AST levels. BMI, body mass index; FGFR4, fibroblast growth factor receptor 4.