Table 2.
Disease-associated factors that impact plasma membrane resistance and repair
| Impact | Protein | Disease | Refs |
|---|---|---|---|
| Lung | |||
| Resistance, repair | CAV1, MG53 | Idiopathic pulmonary fibrosis | [240, 241] |
| Gastrointestinal tract | |||
| Resistance, repair | CAPN8, CAPN9 | Gastropathies | [242] |
| Repair | ANXA4 | Gastric cancer | [243] |
| ATG16L1 | Inflammatory bowel disease | [13] | |
| GPX4 | Inflammatory bowel disease | [19] | |
| Skin | |||
| Resistance | FLG | Atopic dermatitis | [221] |
| Vasculature | |||
| Repair | VWF | Von Willebrand disease | [225] |
| ANXA2 | Behcet’s disease | [244] | |
| Liver | |||
| Resistance | MDR3 | Familial intrahepatic cholestasis | [228] |
| Kidney | |||
| Repair | MG53 | Acute kidney injury | [245] |
| Muscle | |||
| Resistance | DMD | Duchenne’s muscular dystrophy | [246] |
| DAG1 | Dystroglycanopathy | [247] | |
| Repair | DYSF | Limb-girdle muscular dystrophy type 2B | [125] |
| CAV3 | Limb-girdle muscular dystrophy type 1C | [196] | |
| ANO5 | Limb-girdle muscular dystrophy type 2 L | [173] | |
| PTRF | Lipodystrophy | [248] | |
| MICU1 | Neuromuscular disorder | [174] | |
| ANXA6 | Limb-girdle muscular dystrophy type 2C | [249] | |
| ASM | Niemann-Pick type A/B | [235] | |
| CAPN-1, −2, −3 | Calpainopathies | [34, 113, 250] | |
| MCOLN1 | Mucolipidosis type IV | [112] | |
| SYT7 | Autoimmune myositis | [251] | |
| HRK | Myositis | [252] | |
| Heart | |||
| Repair | DYSF | Limb-girdle muscular dystrophy type 2B | [238] |
| MG53 | Valvular heart disease | [253] | |