Figure. Loss of Androgen Receptor (AR) in Humans and Asthma Risk.

Consistent with murine data,⁴ electronic medical record–based analysis of more than 76 million unique patients in Explorys revealed that the odds of having any asthma diagnosis are more than 4 times those in the control group among patients with complete loss of AR function (androgen insensitivity syndrome [AIS]) and 2.65 times those in the control group in patients with partial AIS. Validation for the combined diagnosis was performed in a separate cohort of more than 18 million unique patients in the Indiana Network for Patient Care (Regenstrief), in which asthma risk was more than twice that of control patients in patients with any form of AIS.