Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar 31;70(7):1253–1265. doi: 10.1136/gutjnl-2020-323826

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

Oral microbial restoration along with recovery of patient with COVID-19. (A) Rarefaction analysis between the number of samples and the number of OTUs. As the number of samples increased, the number of OTUs approached saturation in CPs (n=72), CPRs (22) and HCs (n=150). Compared with the HCs, the number of OTUs in CPs and CPRs was decreased. As estimated by the Shannon index, oral microbial diversity in the CPRs was similar to that in the CPs but significantly decreased compared with that in the HCs. (B) The PCoA based on OTU distribution showed that the oral microbial communities in the CPRs were different from those in the CPs and HCs. (C) Along with the recovery of COVID-19, the relative abundances of five genera gradually increased and were significantly different among the three groups, while the abundances of five genera gradually decreased and were significantly different among the three groups. (D) Heatmap for the relative abundances of differential OTUs for each sample in the three groups. The red box represents a gradual increase in abundance of OTUs from left to right and the green box represents a gradual decrease in abundance of OTUs from left to right. *P<0.05, **p<0.01, ***p<0.001. CPs, confirmed patients; CPRs, confirmed patients who recovered; HCs, healthy controls; OTUs, operational taxonomic units; PCoA, principal coordinate analysis. Centerline, median; box limits, upper and lower quartiles; circle or square symbol, mean; error bars, 95% CI.