Table 1.

Inclusion and Exclusion Criteria

Inclusion criteria

• Men and women, 65–84 years of age

• BMI ≥ 25 kg/m2

• Willing to participate and give informed consent

• Family history of dementia, but without personal cognitive impairment (as measured by the Montreal Cognitive Assessment (MoCA) ≥22) [34]

• Must agree to not take non-prescribed vitamin supplements, multi-vitamin or individual supplements of vitamin E, folic acid, n-3 fatty acids, or carotenoids

• Must not have a member of their household already enrolled in the Mind Diet Trial

• Suboptimal diet (MIND screener score 8 or lower out of 14)1

• Successful completion of 3–4 week run-in period

Exclusion criteria

• Have allergy to more than one type of food (nuts, berries, olive oil, or fish)

• Use of medications to treat Alzheimer’s disease or Parkinson’s disease

• Psychosis or bipolar disorder

• Depression or other psychiatric disorders2

• Psychiatric medicines

• Unstable or recent onset of cardiovascular disease, such as myocardial infarction within the previous 6 months or presence of heart failure above Type 1

• Recent onset of stroke or TIA within previous 3 months

• Diagnosis of cancer within previous 5 years except non-melanoma skin cancer2

• History of brain injury, liver disease, Hepatitis C, or HIV

• Illness and diseases related to weight change (i.e., history of stomach or gastrointestinal conditions, inflammatory bowel disease, Crohn’s disease, malabsorption, colostomy, bowel resection, or gastric bypass surgery)2

• Report of alcohol or substance abuse within previous 6 months or heavy alcohol consumption (> 2 drinks/day for women; > 3 drinks/day for men)

¹MIND diet screening instrument and scoring (Supplementary Table 1)

²Clinical judgments by PI and the steering committee