. Author manuscript; available in PMC: 2022 Mar 1.

Published in final edited form as: Contemp Clin Trials. 2021 Jan 9;102:106270. doi: 10.1016/j.cct.2021.106270

Table 4.

Measurements Schedule

Variable	Pre-Screen	SV1	Run-in (Week)				Baseline Visits 1 and 2	Month 3	Month 6	Month 12	Month 24	Month 36
Variable	Pre-Screen	SV1	1	2	3	4	Baseline Visits 1 and 2	Month 3	Month 6	Month 12	Month 24	Month 36
Pre-Screen Eligibility Form	X
Family History AD	X
MIND Diet Screener	X
Consent		X
Health/Med History		X
Montreal cognitive assessment		X
Height		X					X
Weight		X					X		X	X	X	X
Blood Pressure							X		X	X	X	X
Waist Circumference							X		X	X	X	X
Food Records			X	X	X	X
Diet Randomization							X
Initial Diet Instruction							X
MRI¹							X					X
Diet Intervention								X	X	X	X	X
Move Monitor²							X			X	X	X
Fasting Blood draw ³							X	X		X	X	X
Spot Urine⁴							X	X		X	X	X
MIND Interview⁵							X		X	X	X	X
Medication usage questionnaire							X		X	X	X	X
24 hr Dietary Recall							X		X	X	X	X
Food Frequency Questionnaire							X		X	X	X	X
Cognitive Battery⁶							X		X	X	X	X

Sample of 300 participants; 150 at each site; 150 on each diet

Participants from the Rush site will be asked to wear a physical activity sensor (the McRoberts Move Monitor+) on seven consecutive days

Fasting blood collected on participants at baseline and at months 3, 12, 24, and 36. Measures will include abeta40/42, HbA1c, APOE-ε4 genotyping (Baseline ONLY), BDNF, CRP, IL-6, adiponectin, oxidized LDL, total cholesterol, HDL cholesterol, triglycerides, folate, Vitamin B12, tocopherols, carotenoids, and fatty acids.

⁴

Spot urine (Total Polyphenols with creatinine) collected on participants at baseline and at months 3, 12, 24, and 36.

⁵

MIND Interview includes: Medical history, CES-D 10-item, Neuroticism Scale 4-item, Yale Physical Activity Scale, Cognitive Activities, Functional Status, Demographics, and Tobacco usage.

⁶

Cognitive Battery includes: East Boston Immediate Story recall, Multilingual Naming Test, Word List Memory, Word List Recall, Word List Recognition, Pattern Comparison (NIH toolbox) Verbal Fluency, Logical Memory (East Boston delayed story recall), Trails test A and B, Flanker Inhibitory Control (NIH toolbox), Oral Digit Symbol test (NIH toolbox)