Table 4. SNVs Obtained from the in Vitro Evolution of 3D7 and Dd2 Strains of P. falciparum against GNF-Pf-3600.

gene name	description	effect	3D7-3B8	3D7-3E3	3D7-3H7	3D7-4A5	3D7-4A8	3D7-4G6
PF3D7_0305500	conserved Plasmodium protein, unknown function	D1228_D1229del	x	x		x	x	x
PF3D7_0307900	conserved Plasmodium protein, unknown function	L2968F	x	x	x	x	x	x
PF3D7_0307900	conserved Plasmodium protein, unknown function	D1648_Q1650dup	x	x	x	x	x	x
PF3D7_0312500	major facilitator superfamily related transporter, putative	G146R	x	x	x	x	x	x
PF3D7_0501400	interspersed repeat antigen	Q127Q				x
PF3D7_0614300	organic anion transporter	intron variant	x	x		x		x
PF3D7_0929000	conserved Plasmodium protein, unknown function	intron variant				x
PF3D7_1106600	DEAD/DEAH box helicase, putative	N90_N91dup				x
PF3D7_1132400	conserved Plasmodium membrane protein, unknown function	D1030_N1031del	x	x	x	x	x	x
PF3D7_1118500	box C/D snoRNP rRNA 2′-O-methylation factor, putative	H545Y				x	x
PF3D7_1222600	transcription factor with AP2 domain(s)	S2162R						x
PF3D7_1222800	conserved Plasmodium protein, unknown function	intron variant	x	x	x	x	x	x
PF3D7_1314300	conserved Plasmodium protein, unknown function	S197S	x	x	x	x	x	x
PF3D7_1363400	polyubiquitin binding protein, putative	N220_N221dup					x	x
PF3D7_1408200	transcription factor with AP2 domain(s)	N900_N901del	x	x	x	x	x
PF3D7_1470100	conserved Plasmodium protein, unknown function	L2246S				x		x

gene name	description	effect	Dd2-3C11	Dd2-3D2	Dd2-3H5	Dd2-4A8	Dd2-4B10	Dd2-4F4
PF3D7_0310200	phd finger protein, putative	V2606frameshift	x	x	x	x		x
PF3D7_0312500	major facilitator superfamily related transporter, putative	S16R	x	x	x
PF3D7_0312500	major facilitator superfamily related transporter, putative	D150V				x	x	x
PF3D7_0402300	reticulocyte binding protein homologue 1	K1244N			x
PF3D7_0515400	conserved Plasmodium protein, unknown function	C174S	x	x	x
PF3D7_1254500	rifin|PIR protein	Q4H		x				x